The fixture has a small stop incorporated into the base that allows you to drop a series of boards into it and drill them the same each time.
Once the board is in place, you pull the quick-lock down and into place. This lock allows you to release a board without changing the setup for multiple boards. We're locking it into place to do the initial setup.
To set the rest of the offsets and depths, you push down then twist the rear handle. In one event this sets the material thickness, the height of the stop, and tightens the assembly. That's it, you're ready to drill.
The drill order doesn't matter but I always do the primary first because I have a mild (wife says strong) case of OCD. When the collar on the bit hits the stop plate, the stop plate will move about 3/8" until it stops. When it stops moving, you're done. Then drill the secondary (if you're doing two) the same way.
This board is complete. To release the stop, all you need to do is pull up on the clamp to the rear. This moves the assembly back about an 1/4" so you can get the board out however the setting knob remains in place so you won't have setup the fixture again on board change. If your board thickness changes, you will have to reset the knob.
The fixture does have a dust port on the back which allows you to attach a dust collection system (or shop vac) to it. There's a nice trough in the bottom of the fixture where the shavings naturally want to go which aids in their removal. When using dust collection the fixture doesn't require cleaning between boards. Without dust collection you'll have to blow the shavings out before replacing the next board.
The end result is the same every time. I hammered down so the hole edges don't look as great as they could and my bit could probably use a re-sharpen. Though the system is expensive, it really does take the setup out of pocket-holes. When I build a face-frame, the pocket holes are the part of the process I don't think about because it goes so quickly. I never have used the Kreg top-end kit so I can't compare apples to apples however this is the easiest to use fixture I've used so far.