Portable AC units, both air and water cooled, are available in larger sizes but they are used in computer room applications, etc., and are not cost effective. Best bet is a quality window/thru-wall unit.
A shoot from the hip guess would put you in the one ton to one and a half ton size range. The intent (from my perspective) would not be to maintain 72 degrees in the garage as your house is, but to lower the humidity to an acceptable level and to lower the temperature enough so that you would feel comfortable performing normal tasks. Maybe 78 degrees and no more than 50% RH. Perform a load calculation for actual required unit size.
If the garage has at least minimum insulation, and the garage is attached to the house on one or more sides, the biggest sources of heat will be infiltration and solar load. Place shades on all windows and make sure that all seals and gaskets are in good condition. The garage overhead door can be a large source of heat, especially if the garage door is aluminum construction. The solar load on the door is converted to radiant heat in to the garage. Insulate the door if at all possible. Minimizing infiltration will allow you to reduce the humidity. If the garage is not relatively airtight you will lose the battle against moisture infiltration.
I am not sure where in Florida you are located, but if you are along the coast the salt air will be tough on any window unit. Plastics will last longer than coated steels, and a fresh water wash occasionally will help the longevity of the unit. Plan on an expected service life of 5-7 years for the unit.
Route the condensate drain so that you do not have a season-long puddle outside of the unit. Select the highest SEER rating that you can afford. Make certain that electrical circuit is up to the task, and heavy-up the conductor if required. Better quality units have better thermostats and/or temperature controls, and also operate more quietly. For a slight increase in price, you can purchase a unit with reverse-cycle heating, though that will limit your choices with some manufacturers.
With the proper expectations, a window (or PTAC unit) will suit your needs. Good luck with your project.
As always, offered only as opinion