If you have any loam (topsoil), then that has to go. Clay soils can be problematic to build on. Don't pour your new slab on a wet high clay content subsoil. When the clay dries out and shrinks chances are the slab will settle unevenly and develop cracks. Get rid of as much clay as possible. Wait for a dry period (when the ground is most dry), fill in with your gravel/stone and run a plate compactor over the stone. Now you're ready for your wire/rebar and to pour the slab. Use some kind of a bond break or expansion joint to keep the slab from sticking to your foundation walls.
If you dig down and still have a high clay content there is a way of treating the soil with lime to somewhat stabilize it. I have never personally done this, but have heard of it as a solution for building slabs on problematic clay soils.