I had one for about 10 years before moving. I really loved it, though I wish it had more ceiling height. The first thing I recommend is LOTS of light. Without windows you need every bit of help you can get. Recess them into the floor joists if you can so you don't lose any height. I left my ceiling open so that I could get to all the mechanicals of the house. It was a work space anyways, so the unfinished look was ok by me.
Try hard not to put things around those support poles. It'll pile up quickly. Be aware that you're working right below your living space, so if you're welding or painting, keep the doors open, and don't bang on things after the wife/kids are asleep.